Research progress of biosensors for detection of SARS-CoV-2 variants based on ACE2Article Published on 2023-01-012022-11-15 Journal: Talanta [Category] SARS, 변종, 치료기술, [키워드] Accuracy ACE2 acute respiratory syndrome addition antibody biosensor biosensors caused Cell cells complex coronavirus coronavirus disease COVID-19 detect detection Diagnosis drug evaluated gold standard Health increase Interaction modulate Mutation Novel coronavirus pandemic Prevent receptor RT-PCR SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2. the spike protein time-consuming variants Variation virus virus mutations [DOI] 10.1016/j.talanta.2022.123813 PMC 바로가기
Assessing the reporting quality of randomized controlled trials on COVID-19 vaccines: a systematic reviewCOVID-19 백신에 대한 무작위 대조 시험의 보고 품질 평가: 체계적인 검토Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] 임상, [키워드] adverse effect Analysis analysis of variance Assessing CONSORT CONSORT statement controlled trials COVID-19 COVID-19 vaccine COVID-19 vaccines criteria current database effective evaluated Evidence groups independent indicate indicated median Mortality no significant difference predicted Randomized Randomized controlled trial Randomized controlled trials RCT RCTs reported Reporting Reporting quality review. Standard systematic review Univariate analysis variance variety [DOI] 10.1080/21645515.2022.2031453 PMC 바로가기 [Article Type] Article
Changes of Routine Hematological Parameters in COVID-19 Patients: Correlation with Imaging Findings, RT-PCR and OutcomeOriginal Article Published on 2022-12-152022-10-29 Journal: Iranian Journal of Pathology [Category] COVID-19, [키워드] Admission age analyses Biochemical parameters Blood change Chest chest imaging Chest tomography Concentration Coronavirus disease 2019 correlated correlation correlations COVID-19 COVID-19 case COVID-19 patient Critical CRP CT-scan demonstrated diagnosed Diagnosis during admission enrolled evaluated expired group hematologic hematology hemoglobin Hospitalized imaging investigated Laboratory LDH less leukocyte lung lung involvement Lymphocytes neutrophil no increase outcome parameter parameters participant Patient patients Platelet platelets count Prognostic value raise researcher respiratory viral routine RT-PCR severity Severity of disease the disease tomography Tomography scanners upper respiratory Viral load WBC were measured White blood cells [DOI] 10.30699/IJP.2021.533645.2675 PMC 바로가기 [Article Type] Original Article
Sewage surveillance of SARS-CoV-2 at student campus residences in the Western Cape, South AfricaArticle Published on 2022-12-102022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] activity acute respiratory syndrome Cape collected coronavirus coronavirus disease country COVID-19 defined Delta diagnostic Efficacy Epidemiology evaluated genotyping Infection infections institution management monitoring Near-source WBE omicron outbreak Passive Passive sampling reported RT-qPCR SARS-CoV-2 sewage South Africa Stellenbosch Stellenbosch University student Student campus residences Surveillance Thermo Fisher variant wastewater Wastewater-based epidemiology. [DOI] 10.1016/j.scitotenv.2022.158028 PMC 바로가기
Sputum characteristics of patients with severe COVID-19: report of two cases with immunocytochemical detection of SARS-CoV-2 spike proteinArticle Published on 2022-12-012022-11-15 Journal: Medical molecular morphology [Category] COVID19(2023년), SARS, 치료기술, [키워드] aggregation alveolar Analysis can be used CD68 Cell cells characteristics of patient chromatin COVID-19 cytological cytoplasmic definitive diagnosis double infection epithelial evaluated exclusion expression Herpe herpes simplex herpes simplex virus immunocytochemistry Inclusion infected cell Infection intranuclear multinuclear nuclear nuclei Patient performed pneumocyte positive protein A SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein severe COVID-19 simplex specimen sputum Sputum sample Sputum. staining These cells Treatment viral infection virus [DOI] 10.1007/s00795-022-00326-9 PMC 바로가기
Heterologous boosting with third dose of coronavirus disease recombinant subunit vaccine increases neutralizing antibodies and T cell immunity against different severe acute respiratory syndrome coronavirus 2 variants코로나바이러스 질병 재조합 소단위 백신의 세 번째 용량으로 이종 부스팅은 다양한 중증 급성 호흡기 증후군 코로나바이러스 2 변이체에 대한 중화 항체 및 T 세포 면역을 증가시킵니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Anti-RBD IgG anti-S booster vaccination CD4+ T cell components composite pattern coronavirus coronavirus disease COVID-19 COVID-19 vaccinations COVID-19 vaccine dose effective epitope Epitopes evaluated Evidence help Heterologous heterologous boosting homologous Humoral immunity Immune escape Immunity immunization strategy immunological in some inactivated Inactivated vaccine increase magnitude NAb NAbs natural infection Neutralizing Neutralizing antibodies neutralizing antibody neutralizing capacity omicron pandemic prime-boost strategy produced RBD IgG respiratory subunit Subunit vaccine Subunit vaccine. T cell T cell response T cells titre vaccination Vaccination strategies Vaccination strategy Vaccine Vaccine-induced immunity variant variants of concern waned [DOI] 10.1080/22221751.2022.2048969 PMC 바로가기 [Article Type] Article
Zinc pyrithione is a potent inhibitor of PL Pro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication아연 피리티온은 SARS-CoV-2 진입 및 복제를 생체 외에서 억제하는 PL Pro 및 카텝신 L 효소의 강력한 억제제입니다.Article Published on 2022-12-012022-09-11 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID19(2023년), SARS, 치료제, [키워드] analogue Anti-SARS-CoV-2 Activity Antiviral antiviral activity Antiviral agents assays cathepsin L comparable complex complexes contrary COVID-19 effective enzyme Enzymes evaluated Ex vivo expressed human lung tissue in vitro inhibition inhibitor involved Ligand media Pro pyrithione Replication ruthenium SARS-CoV-2 SARS-CoV-2 entry stability synthesised therapeutic therapeutic agent Zinc Zinc complexes Zinc pyrithione zinc. [DOI] 10.1080/14756366.2022.2108417 PMC 바로가기 [Article Type] Article
Skin capillary alterations in patients with acute SarsCoV2 infectionArticle Published on 2022-12-012022-11-16 Journal: Journal of hypertension [Category] COVID19(2023년), SARS, 치료기술, [키워드] A significant reduction acute infection acute phase addition alteration Angiogenesis Autopsy blood chemistry C-reactive protein capillary complications correlation COVID-19 demonstrated discharge endothelial damage Endothelial dysfunction Endothelitis evaluated events Evidence explain hospital impairment incidence increase in Infection Inflammation Inflammatory marker inverse correlation Ischemia lymphocyte material oedema organ parameter Patient patients procoagulant promote repeated resulting skin the disease thrombosis tissue vascular effect vasoconstriction viral infection with COVID-19 [DOI] 10.1097/HJH.0000000000003271 PMC 바로가기
Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDSSARS-CoV-2에 의해 유발된 ARDS 생존자의 폐 기능 및 방사선학적 특징과 관련된 순환 microRNA 프로파일 식별Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory distress syndrome Anti-inflammatory ARDS association carbon monoxide cell death Chest computed tomography circulating Coagulation Complete composed Computed tomography conducted correlated COVID-19 develop diffusing diffusing capacity distress enrichment analyses enrichment analysis evaluated Evidence evidence of feature Features Follow-up Gene ontology genomes hospital discharge hypoxia identification immune response infected patient infected patients KEGG KEGG pathway Kyoto lung Lung function median microRNA miR-126 miR-146 miR-146a-5p miR-21 miR-9 miRNA miRNA profiles miRNA profiling miRNA signature molecular molecular mechanism molecular mechanisms Pathogenesis pathophysiology pathway Patient patients predicted profile provided Pulmonary function radiologic radiological feature radiological features Random forest respiratory distress Respiratory distress syndrome RT-qPCR SARS-COV-2 infection secondary to sequelae severe COVID-19 severity survivor to define total severity score. Trial registration TSS vascularization viral infection was performed was used [DOI] 10.1080/22221751.2022.2081615 PMC 바로가기 [Article Type] Article
Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: evidence from a randomized double-blind clinical trialRandomized Controlled Trial Published on 2022-12-012022-10-05 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 임상, [키워드] antiseptic mouthwashe cell cultures cetylpyridinium chloride clinical trial COVID-19 COVID-19 patients Culture double-blind Effect evaluated Evidence in vitro in vivo indicated Infectivity Mouthwash mouthwashe mouthwashes not affected Placebo placebo-controlled clinical trial quantitative PCR Randomized reduce reduced reducing Saliva Saliva. salivary SARS-CoV-2 shown significantly tested viability viral infectivity Viral load Viral transmission virucidal [DOI] 10.1080/22221751.2022.2098059 PMC 바로가기 [Article Type] Randomized Controlled Trial